Research & Economic Development

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Method of Using β-aminoisobutyric Acid (BAIBA) to Prevent Deterioration of the Musculoskeletal


UMKC inventors have discovered that administering β-aminoisobutyric acid to an inactive individual preserves bone homeostasis and prevents deterioration of bone and other tissues of the musculoskeletal system.

Need:

As the population ages, there is an increasing prevalence of musculoskeletal conditions that are becoming a major healthcare burden. Approximately 126.6 million adults suffer from some form of mus-culoskeletal disease, which accounts for 18% of all office visits, and has caused an estimated 291 million lost work days. The combined economic impact and healthcare costs are estimated at $874 billion or 5.7% GDP. There is a clear unmet need to decrease the healthcare and economic burden associated with musculoskeletal diseases.

Invention Details:

BAIBA is a small molecule myokine that is generated by the catabolism of the amino acid valine during exercise. Studies have demonstrated that BAIBA production increases in the plasma during exercise and decreases many metabolic risk factors. Inventors at UMKC have built upon this data and demonstrated that BAIBA protects osteocytes from cell death caused by the production of reac-tive oxygen species (ROS). Working through the Mas-Related G-Protein Coupled Receptor, BAIBA was able to prevent mitochondrial breakdown caused by ROS. In an in vivo model for muscle disuse, BABIA administered in the drinking water (100 mg/kg/day) protected mice against bone and muscle loss. This protection is mainly observed in young mice. This data suggests that BABIA administration may prevent muscle and/or bone loss associated with aging and has the potential to help treat musculoskeletal dis-eases.

Advantages:

Currently, the treatment for many of the musculoskeletal diseases are lacking and are mainly palliative. This technology has the potential to be used to treat painful and debilitating musculo-skeletal diseases or prevent further tissue destruction

Suggested Uses:

The invention has the potential to impact therapeutic areas such as:
* The elderly or to patients that will be immobilized for extended periods of time due to accidents, sports related injuries, or illnesses to prevent muscle deterioration.
* Cancer patients to prevent cachexia.
* Treatments for osteoporosis.
* Aid in the treatment of muscular diseases.

Technology Summary