Research & Economic Development

Office of the Vice Chancellor

What is a Congruency Review?

A congruency review is a side by side comparison of a proposal (grant, award, contract, subaward, etc.) to a protocol to ensure that all animal activity outlined in that proposal has been approved by the UMKC IACUC and is contained in an approved animal protocol.  A congruency review is required for all funding that uses live vertebrate animals to ensure the work described in the proposal comports with an active, approved protocol. UMKC has a one-to-many/many-to-one system which means one funded proposal can be linked to one or many protocols, and one protocol can be linked to one or many proposals.

What are we looking for during our review?

The items we look at during our review include but are not limited to: 

  • General scope of work - disease area, target organs, and/or biological target being studied, etc.
  • Species – sex, age, numbers, strains, potential clinical issues, breeding, etc.
  • General procedures including administration of agents, blood/tissue collection, antibody generation, imaging, behavioral studies, etc.
  • Experimental and therapeutic agents.
  • Surgical procedures.
  • Euthanasia method.
  • Death as an endpoint – any procedures that suggest death as an endpoint (USDA pain category E) or survival curves generated (Note:  if a modification to the protocol is required to cover death as an endpoint studies, that modification must be reviewed by the full IACUC committee at a monthly IACUC meeting).
  • Personnel conducting animal work.