Office of
Research Services

IBC Application Documents

IBC approval of recombinant or synthetic nucleic acid molecules and biohazardous research protocols is effective for three years.

PIs must complete an IBC Annual Renewal each year to continue work for up to three years after the initial approval. After three years, the application must be resubmitted and reviewed by the committee.

What needs IBC approval?

  • Recombinant or synthetic nucleic acid molecules
  • Hazardous biological agents (virus, bacteria, fungi, parasite, prion, rickettsia etc.)
  • Other potentially infectious materials (human or non-human primate blood, serum, plasma, body fluids, unfixed tissue, organ and cells)
  • Biological toxins including select agent toxins
  • Inactivated Biological Samples derived from BSL-3 or BSL-4 agents
  • Attenuated pathogens derived from BSL-3 or BSL-4 agents
  • Human gene transfer
  • Transgenic animals or plants


See NIH Guidelines (PDF) for additional information.